Publications / Grants

Peer reviewed original paper (15 papers)

2020

Combined Cohesin-Runx1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes

Y. Ochi, A. Kon, T. Sakata, M. M. Nakagawa, N. Nakazawa, M. Kakuta, K. Kataoka, H. Koseki, M. Nakayama, D. Morishita, T. Tsuruyama, R. Saiki, A. Yoda, R. Okuda, T. Yoshizato, Y. Shiozawa, Y. Nannya, S. Kotani, Y. Kogure, N. Kakiuchi, T. Nishimura, H. Makishima,  L. Malcovati, A. Yokoyama, K. Takeuchi, E. Sugihara, T. A. Sato, M. Sanada, A. Takaori-Kondo, M. Cazzola, M. Kengaku, S. Miyano, K. Shirahige, H. I. Suzuki, S. Ogawa

Cancer Discovery, 2020 Jun;10(6):836-853. doi: 10.1158/2159-8290.CD-19-0982. Epub 2020 Apr 5.

Stopping transformed cancer cell growth by rigidity sensing

Bo Yang, H. Wolfenson, V. Y. Chung,  N. Nakazawa, S. Liu, J. Hu, R. YJ. Huang,  M. P. Sheetz

Nature Materials, Vol. 19, 239-250 (2020)

2018

Chiral cell sliding drives left-right asymmetric organ twisting

M. Inaki, R. Hatori,  N. Nakazawa, T. Okumura, T. Ishibashi, J. Kikuta, M. Ishii, K. Matsuno, H. Honda

eLife, Jun. 12;7 (2018)

2017

Mechanotransmission and Mechanosensing of Human alpha-Actinin 1

S. Le, X. Hu, M. Yao, H. Chen, M. Yu, X. Xu, N. Nakazawa, F. M. Margadant, M.P. Sheetz, J. Yan

Cell Reports, Vol. 21, No.10, 2714-2723 (2017)

2016

Matrix mechanics controls FHL2 movement to the nucleus to activate p21 expression

N. Nakazawa, A.R. Sathe, G.V. Shivashankar, and M.P. Sheetz

Proc. Natl. Acad. Sci. USA (PNAS), Vol.113, No.44, E6813-E6822 (2016)

Cooperative Vinculin binding to Talin mapped by time resolved super resolution microscopy

X. Hu, C. Jing, X. Xu, N. Nakazawa, V. W. Cornish, F. Margadant, M. P. Sheetz

Nano letters, Vol.16, No.7, 4062-4068 (2016)

2015

Genetic analysis of Drosophila Class I Myosin genes in Left-Right asymmetric development

T. Okumura, T. Sasamura, M. Inatomi, S. Hozumi, M. Nakamura, R. Hatori, K. Taniguchi, N. Nakazawa, E. Suzuki, R. Maeda, T. Yamakawa, and K. Matsuno

Genetics, Vol.199, 1183-1199 (2015)

2014

Left-right asymmetry is formed in individual cells by intrinsic cell chirality

R. Hatori, T. Ando, T. Sasamura, N. Nakazawa, M. Nakamura, K. Taniguchi, S. Hozumi, J. Kikuta, M. Ishii, K. Matsuno

Mechanisms of Development, Vol.133, 146-162 (2014)

2013

Reduced cell number in the hindgut epithelium disrupts hindgut left–right asymmetry in a mutant of , encoding a RhoGEF, in  embryos

M. Nakamura, K. Matsumoto, Y. Iwamoto, T. Muguruma, N. Nakazawa, R. Hatori, K. Taniguchi, R. Maeda, K. Matsuno

Mechanisms of Development, Vol.130, 169-180 (2013)

2012

A novel Cre/loxP system for mosaic gene expression in the Drosophila embryo

N. Nakazawa, K. Taniguchi, T. Okumura, R. Maeda, and K. Matsuno

Developmental Dynamics, Vol.241, 965-974 (2012)

Canonical Wnt signaling in the visceral muscle is required for left-right asymmetric development of the midgut

J. Kuroda, M. Nakamura, M. Yoshida, H. Yamamoto, T. Maeda, K. Taniguchi, N. Nakazawa, R. Hatori, A. Ishio, A. Ozaki, S. Shimaoka, T. Ito, H. Iida, T. Okumura, R. Maeda, K. Matsuno

Mechanisms of Development, Vol.128, 625-639 (2012)

Deficient Notch signaling associated with neurogenic is compensated for by the unfolded protein response in Drosophila

T. Yamakawa, K. Yamada, T. Sasamura, N. Nakazawa, M. Kanai, E. Suzuki, M. E. Fortini, and K. Matsuno

Development, Vol.139, 558-67 (2012)

2011

Chirality in Planar cell shape contributes to left-right asymmetric epithelial morphogenesis

K. Taniguchi, R. Maeda, T. Ando, T. Okumura, N. Nakazawa, R. Hatori, M. Nakamura, S. Hozumi, H. Fujiwara, K. Matsuno

Science, Vol.333, 339-341 (2011)

2010

Left-right asymmetric morphogenesis of the anterior midgut depends on the activation of a non-muscle myosin II in Drosophila

T. Okumura, H. Fujiwara, K. Taniguchi, J. Kuroda, N. Nakazawa, M. Nakamura, R. Hatori, A. Ishio, R. Maeda, K. Matsuno

Developmental Biology, Vol.344, 693-706 (2010)

2008

Head region of unconventional Myosin I family members is responsible for the organ-specificity of their roles in left-right polarity in Drosophila

S. Hozumi, R. Maeda, M. T. Kanai, T. Okumura, K. Taniguchi, Y. Kawakatsu, N. Nakazawa, R. Hatori, and K. Matsuno

Developmental Dynamics, Vol.237, 3528-3537 (2008)

Peer reviewed review paper (1 paper)

2020

Mechanical regulation of nuclear translocation in migratory neurons

N. Nakazawa* and M. Kengaku (*Corresponding author)

Frontiers in Cell and Developmental Biology, 8:150 (2020)

Preprint (2 paper)

2022

The Drosophila AWP1 ortholog Doctor No regulates JAK/STAT signaling for left-right asymmetry in the gut by promoting receptor endocytosis

Lai E., T. Sasamura, J. Kuroda, R. Maeda, M. Nakamura, R. Hatori, T. Ishibashi, K. Taniguchi, M. Ooike. T. Taguchi, N. Nakazawa, S. Hozumi, T. Okumura, T. Aigaki, M. Inaki, K. Matsuno

bioRxiv, 2022

2018

Stopping transformed cell growth with cytoskeletal proteins: Turning a Devil into an Angel

Bo Yang, H. Wolfenson, N. Nakazawa, S. Liu, J. Hu, M. P. Sheetz

bioRxiv, 2018

Invited review paper (Japanese x 3 papers)

脳発生に寄与するニューロン遊走のメカノバイオロジー

中澤 直高、見学 美根子

生体の科学, Vol.70, No.4 (2019)


留学先における体験談-人間関係にフォーカスして-

中澤 直高

実験医学, Vol.33, No.18 (2015)


左右非対称な組織形態形成の新たな機構-上皮細胞における平面内細胞形状のキラリティの意義-

中澤 直高、 谷口喜一郎、 前田礼男、 安藤格士、 松野健治

実験医学, Vol.30, No.1, 75-78 (2012)

Grants

FY2021~2024

プレッシオ脳神経科学の促進・発展

学術変革領域研究(B)・総括班

代表者:野々村 恵子(東京工業大学)・分担者:中澤 直高(京都大学・近畿大学)、平田 宏聡(金沢工業大学)、森松 賢順(岡山大学)

脳脊髄液圧依存的な組織伸展と神経幹細胞への圧縮刺激による神経発生の調節機構の解明

学術変革領域研究(B)・計画研究

代表者:中澤 直高(京都大学・近畿大学)

FY2021

脳組織における狭小な空間のニューロン遊走を駆動する分子機構の解明

ライフサイエンス研究助成

代表者:中澤 直高(京都大学)

FY2018~2022

新規素材とマイクロ加工技術で再現する脳微小空間を用いたニューロン遊走機構の解析

国際共同研究強化(B)

代表者:見學 美根子(京都大学)・分担者:宇都 甲一郎(物質・材料研究機構)、中澤 直高(京都大学)

FY2010~2012

ショウジョウバエを用いた左右対称性を破る新規な機構の解明

日本学術振興会特別研究員 奨励費

代表者:中澤 直高(東京理科大学)